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In order to demonstrate that the 127 gene signature is related to regional emphysema severity within individuals and not to differences between donors and COPD patients or to differences in levels of emphysema between COPD patients, we repeated the same statistical analysis while only including the five COPD patients with emphysema and standardizing the Lm measurements within each patient core to a mean of zero and a standard deviation of one (Z-score)

By activating the parasympathetic nervous system and assisting patients in recognizing the relationship between stress and dietary habitssuch as through the Mindful Eating Questionnaire (MEQ) and handwritten dietary journalsit helps reduce stress responses and enhance digestive function, thereby promoting more favorable conditions for nutrient absorption